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Friday, July 31, 2020 | History

4 edition of The Transformation-associated cellular p53 protein found in the catalog.

The Transformation-associated cellular p53 protein

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  • 26 Currently reading

Published by Raven Press in New York .
Written in English

    Subjects:
  • Carcinogenesis.,
  • Viral carcinogenesis.,
  • SV40 (Virus),
  • Viral cell transformation.,
  • Tumor antigens.,
  • Cell transformation, Neoplastic.,
  • Cell transformation, Viral.,
  • Neoplasm proteins.

  • Edition Notes

    Includes bibliographical references and index.

    Other titlesp53 protein.
    Statementeditor, George Klein.
    SeriesAdvances in viral oncology ;, v. 2
    ContributionsKlein, George, 1925-
    Classifications
    LC ClassificationsRC268.5 .T68 1982
    The Physical Object
    Paginationxii, 180 p. :
    Number of Pages180
    ID Numbers
    Open LibraryOL3491406M
    ISBN 100890048576
    LC Control Number82011209

      As cellular senescence is largely dependent on activation of the p19 Arf –p53 pathway in MEFs 2,21,22, we determined whether this pathway is activated in Pten +/- . Advances in Viral Oncology, Volume 2: The Transformation-Associated Cellular p53 Protein, Klein, George (Ed.): Published by New York, Raven Press, ().

    Abstract. The cellular phosphoprotein p53 is associated with cell proliferation and is synthesized in normal, actively dividing cells, including fresh lymphocytes and primary cultures derived from rodent embryos (reviewed in Crawford, ; Jenkins and Sturzbecher, ). p53 expression increases following mitogenic stimulation of resting cells (Milner and Milner, ; Reich and Levine, The p53 protein is mutated in about 50% of human cancers. Aside from losing the tumor-suppressive functions of the wild-type form, mutant p53 proteins often acquire inherent, novel oncogenic functions, a phenomenon termed mutant p53 gain-of-function (GOF). A growing body of evidence suggests that these pro-oncogenic functions of mutant p53 proteins are mediated by affecting the transcription.

    p53 is a tumor suppressor protein, also known as "Guardian of the Genome". It plays an important role in cell cycle control and apoptosis. Defective p53 could allow abnormal cells to proliferate, resulting in cancer. As many as 50% of all human tumors contain p53 mutants. In normal cells, the p53 protein . Rb, p53, and p21 act primarily at the G 1 checkpoint. p53 is a multi-functional protein that has a major impact on the commitment of a cell to division because it acts when there is damaged DNA in cells that are undergoing the preparatory processes during G 1. If damaged DNA is detected, p53 halts the cell cycle and recruits enzymes to repair.


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The Transformation-associated cellular p53 protein Download PDF EPUB FB2

Advances in Viral Oncology: The Transformation - Associated Cellular P53 Protein by George Klein (Editor) ISBN ISBN Why is ISBN important. ISBN. This bar-code number lets you verify that you're getting exactly the right version or edition of a book.

The digit and digit formats both work. The origins of p53 in relation to transformation / Lionel Crawford--The complex between p53 and SV40 T antigen / D.P. Lane, J. Gannon, and G. Winchester --Monoclonal antibody analysis of p53 / Elizabeth G.

Gurney --Control of cellular levels of the transformation associated K proteins (p53s) / Pierre May, Evelyne May, and Michel Kress. Cite this article.

Jenkins, J., Rudge, K. & Currie, G. Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein pCited by: Rotter V, Abutbul H, Ben-Ze'ev A. P53 transformation-related protein accumulates in the nucleus of transformed fibroblasts in association with the chromatin and is found in the cytoplasm of non-transformed fibroblasts.

EMBO J. ; 2 (7)– [ PMC free article ] [ Cited by:   The transformation-associated cellular protein p53 (/, 2} has been shown to associate with two unrelated viral proteins. In cells that are transformed by SV40, p53 is physically complexed with the viral large T anti- gen ().

In adenovirus type 5 (Ad5)-transformed cells, p53 protein is associated The Transformation-associated cellular p53 protein book the E1B 58, (58K)-Da protein (6).Cited by:   VIROLOGY() The Cellular Tumour Antigen p Evidence for Transformation-Related, Immunological Variants of p53 JO MILNER1 AND ALISTAIR COOK Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, United Kingdom Received March Sl, ; accepted June S, The protein p53 is involved in the control of normal cell proliferation.

Benchimol S, Lamb P, Crawford LV, Sheer D, Shows TB, Bruns GA, Peacock J. Transformation associated p53 protein is encoded by a gene on human chromosome Somat Cell Mol Genet. Sep; 11 (5)– Benchimol S, Pim D, Crawford L. Radioimmunoassay of the cellular protein p53 in mouse and human cell lines.

EMBO J. ; 1 (9)– Christopher L. Bowlus, in Autoantibodies (Third Edition), Abstract. The p53 molecule is a tumor suppressor that prevents the outgrowth of aberrant cells by inducing cell cycle arrest, DNA repair, or programmed cell death. On healthy cells, p53 is barely detectable.

In contrast, most tumor cells manifest an accumulation of p53 protein. A clone that cross-hybridizes with a mouse p53 probe has been isolated from a cDNA library of simian virus transformed human fibroblasts. This cloned human p53 cDNA was used as a probe to examine DNAs obtained from human-rodent somatic cell.

Rotter V. p53, a transformation-related cellular-encoded protein, can be used as a biochemical marker for the detection of primary mouse tumor cells.

Proc Natl Acad Sci U S A. May; 80 (9)– The E6 protein encoded by the oncogenic human papillomavirus types 16 and 18 is one of two viral products expressed in HPV-associated cancers. E6 is an oncoprotein which cooperates with E7 to immortalize primary human keratinocytes. Insight into the mechanism by which E6 functions in oncogenesis is provided by the observation that the E6 protein encoded by HPV and HPV can.

Abstract. p53 is a kDa nuclear protein that is associated with malignant transformation in several tumor model systems. In a survey of human carcinomas, sarcomas, leukemias, and lymphomas obtained at surgery or from peripheral blood, we found rearrangements of the p53 gene only in osteogenic sarcomas (3 of 6 osteogenic sarcomas examined).

Protein P Protein p53 is a tumor suppressor that triggers apoptosis via multiple pathways, including cell cycle arrest and the regulation of autophagy through transactivating proapoptotic and repressing antiapoptotic genes,70 It is highly conserved and regulates cell death resulting from a wide variety of both physiologic and pathologic stimuli.

p53 (or tp53) is a gene vital to many forms of life, including humans. It codes for a protein which suppresses has been called "the guardian of the genome". The p53 gene is the most frequently mutated gene (>50%) in human cancer. Its protein product binds to DNA and regulates gene expression to prevent mutations of the genome.

p53 protein (TP53) is at low levels in human embryonic. The tumour suppressor protein p53 is stabilised and activated in response to ionising radiation. This is known to depend on the kinase ATM; recent results suggest ATM acts via the downstream kinase Chk2/hCds1, which stabilises p53 at least.

The cellular phosphoprotein p53 is presumably involved in simian virus 40 (SV40)-induced transformation. We have monitored changes in the state of phosphorylation of p53 from normal versus SVinfected or -transformed cells. In normal cells, p 53 was hardly phosphorylated.

The p53 protein activates other genes whose products halt the cell cycle (allowing time for DNA repair), activates genes whose products participate in DNA repair, or activates genes that initiate cell death when DNA damage cannot be repaired.

A damaged p53 gene can result in the cell behaving as if there are no mutations (Figure ). Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type.

Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process.

One of the activated genes is an inhibitor of cyclin-dependent kinases. Figure The role of normal p53 is to monitor DNA and the supply of oxygen (hypoxia is a condition of reduced oxygen supply). If damage is detected, p53 triggers repair mechanisms. If repairs are unsuccessful, p53 signals apoptosis.

A cell with an abnormal p53 protein cannot repair damaged DNA and thus cannot signal apoptosis. Most of these are missense mutations, changing the information in the DNA at one position and causing the cell to build p53 with an error, swapping an incorrect amino acid at one point in the protein chain.

In these mutants, the normal function of p53 is blocked and the protein is unable to stop multiplication in the damaged cell. The p53 cellular tumor antigen is a phosphoprotein which is overproduced in a wide variety of neoplastic cells (reviewed by Klein ; Crawford ; Rotter and Wolf ).

High p53 mRNA levels are also seen in certain nonmalignant cells, including embryonic tissue and exponentially growing, non-transformed cultured cell lines, but expression.p53 Signaling Pathway p53 is maintained at low protein levels during times of homeostasis, when the cell is not exposed to stress or DNA-damaging events, by its predominant negative regulator Mdm2 through the ubiquitin-proteasome pathway.

The Mdm2 E3 ubiquitin ligase represses p53 protein levels through continuous ubiquitination and degradation.a, Tumour cells that expressed wild-type p53 protein released vesicles containing small RNA molecules called microRNAs (miRNAs) that were taken up by neighbouring neurons.

An miRNA known as miR.